Numb was originally discovered as an intrinsic cell fate determinant in Drosophila by antagonizing Notch signaling.The present study is to characterize the role of Numb in oxidative stress-induced apoptosis of renal proximal tubular cells.Exposure of NRK52E cells to puromycin aminonucleoside (PA) resulted in caspase 3-dependent apoptosis.Numb expre
This study examines listening effort, as indexed by pupil dilation, needed for processing foreign-accented speech that varies in intelligibility.Previous research has shown that the magnitude of pupil dilation is influenced by various factors, crucially the amount of noise added to speech.However, the method has not yet been used to examine foreign
Background & objectives: Malaria remains a significant public health challenge globally, with an estimated 249 million cases reported across 85 endemic countries and regions in 2022, reflecting an increase of 5 million cases from the previous year.Anopheles mosquitoes are the primary vectors responsible for transmitting malaria parasites to humans,
On 8 October 2017, persistent heavy rainfall triggered a rock collapse on Fenghuang Mountain in Wuxi Town, located within la colors mega grow the Three Gorges Reservoir region of China.Subsequent field investigations and monitoring identified several potentially unstable rock masses in the area, posing a significant threat to the safety of nearby r
Coronavirus disease 2019 (COVID-19) requires admission to intensive care (ICU) for the management of acute respiratory distress syndrome in about 5% of cases.Although our understanding of COVID-19 is still incomplete, a growing body of evidence is indicating potential direct deleterious effects on the enforcer wave to open central and peripheral ne